148 research outputs found

    Death and Display in the North Atlantic: The Bronze and Iron Age Human Remains from Cnip, Lewis, Outer Hebrides

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    YesThis paper revisits the series of disarticulated human remains discovered during the 1980s excavations of the Cnip wheelhouse complex in Lewis. Four fragments of human bone, including two worked cranial fragments, were originally dated to the 1st centuries BC/AD based on stratigraphic association. Osteoarchaeological reanalysis and AMS dating now provide a broader cultural context for these remains and indicate that at least one adult cranium was brought to the site more than a thousand years after the death of the individual to whom it had belonged

    Atlas Toolkit: Fast registration of 3D morphological datasets in the absence of landmarks

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    Image registration is a gateway technology for Developmental Systems Biology, enabling computational analysis of related datasets within a shared coordinate system. Many registration tools rely on landmarks to ensure that datasets are correctly aligned; yet suitable landmarks are not present in many datasets. Atlas Toolkit is a Fiji/ImageJ plugin collection offering elastic group-wise registration of 3D morphological datasets, guided by segmentation of the interesting morphology. We demonstrate the method by combinatorial mapping of cell signalling events in the developing eyes of chick embryos, and use the integrated datasets to predictively enumerate Gene Regulatory Network states

    Evaluation of approaches to generation of tissue-specific knock-in mice

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    eMouseAtlas Informatics:Embryo Atlas and Gene Expression

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    A significant proportion of developmental biology data is presented in the form of images at morphologically diverse stages of development. The curation of these datasets presents different challenges to that of sequence/text-based data. Towards this end, the eMouseAtlas project created a digital atlas of mouse embryo development as a means of understanding developmental anatomy and exploring the relationship between genes and development in a spatial context. Using the morphological staging system pioneered by Karl Theiler, the project has generated 3D models of post-implantation mouse development and used them as a spatial framework for the delineation of anatomical components and for archiving in situ gene expression data in the EMAGE database. This has allowed us to develop a unique online resource for mouse developmental biology. We describe here the underlying structure of the resource, as well as some of the tools that have been developed to allow users to mine the curated image data. These tools include our IIP3D/X3DOM viewer that allows 3D visualisation of anatomy and/or gene expression in the context of a web browser, and the eHistology resource that extends this functionality to allow visualisation of high-resolution cellular level images of histology sections. Furthermore, we review some of the informatics aspects of eMouseAtlas to provide a deeper insight into the use of the atlas and gene expression database

    Geophysical investigation of the neolithic Calanais landscape

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    YesThe northern and western isles of Scotland have proved fertile ground for archaeological investigation over the last 100 years. However, the nature of the landscape with its rugged coastlines and irregular topography, together with rapid peat growth rates, make for challenging surveying. Commonly, an archaeological monument or series of monuments is identified but little is known about the surrounding areas and, in particular, the palaeo-landscapes within which the monuments are located. This situation is exemplified by the standing stones of Calanais in Lewis. Here, surrounding peat bogs have buried a significant portion of the landscape around which the stones were first erected. This project identifies remote sensing geophysical techniques that are effective in mapping the buried (lost) landscape and thus aid better contextualisation of the stone monuments within it. Further, the project demonstrates the most appropriate techniques for prospecting across these buried landscapes for as yet unidentified stone features associated with the lives of the people who constructed the monuments.Scottish EnterpriseResearch Development Fund Publication Prize Award winner, December 2019

    A Model of Coastal Wetland Palaeogeography and Archaeological Narratives : Loch Spynie, Northern Scotland

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    This paper presents a new model for the palaeogeography of an important archaeological region in northern Scotland – the former Loch Spynie, Moray. The method employed refines existing glacio-isostatic adjustment and relative sea-level models for the Holocene with open data sources of geomorphological, geotechnical and archaeological data to constrain the proposed former extent of marine, estuarine and other wetland environment through time. The study area is shown to be an important isolation basin that is highly likely to preserve dateable relative sea-level index points. The resulting palaeogeographic model for the former Loch Spynie estuary is then used to develop an archaeological narrative of coastal and maritime activity in later prehistory critiquing and supporting an emergent paradigm in understanding later prehistory in northern Scotland. This study demonstrates how it is possible to develop palaeogeographic models at scales useful for site-based archaeological interpretation bridging a problematic gap in archaeological narratives
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